urn:taro:utsa.00323 Inventory of the George Perry Papers, 1973-2010 2012 October 19Encoded in XMetal Author by Sean Heyliger. Finding aid is in English . Descriptive Summary Perry, George, 1953-. George Perry Papers 1973-2010 Materials are in English. UA 99.0020 52 linear feet (52 boxes) + 38, 839 electronic files (6.21 GB) University of Texas at San Antonio Libraries Special Collections George Perry is a neuroscientist and Dean of the College of Sciences and Professor of Biology at the University of Texas at San Antonio and a leading researcher in the field of Alzheimer's disease. The George Perry Papers include correspondence, email, grant files, committee files, drafts, laboratory notes, conference files, and slides that document his academic career and research activities primarily related to the cytopathology of Alzheimer's disease. Biographical Note

George Perry is a neuroscientist and Dean of the College of Sciences and Professor of Biology at the University of Texas at San Antonio and a leading researcher in the field of Alzheimer's disease. Born April 12, 1953 in Lompoc, California, Perry received his bachelor's of arts degree in Zoology from University of California, Santa Barbara in 1974 and his PhD in Marine Biology from Scripps Institution of Oceanography of University of California at San Diego in 1979. He then received a postdoctoral fellowship in the Department of Cell Biology in the laboratories of Dr. Bill Brinkley, Joseph Bryan and Anthony R. Means at Baylor College of Medicine, where his research focused on cytoskeletal abnormalities. In 1995, Perry joined the faculty of Case Western Reserve University, where he eventually became Professor of Pathology in the School of Medicine and where he currently holds an adjunct appointment. Since 2005, he has been the Dean of the College of Sciences and Professor of Biology at the University of Texas at San Antonio.

Perry's research focuses on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer disease. His research explores how oxidative damage plays a role in the initial cytopathological abnormality in Alzheimer disease and the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. His research also looks at the metabolic basis for mitochondrial damage restricted to vulnerable neurons, and the consequences of RNA oxidation on protein synthesis rate and fidelity.

With over 900 publications, Perry is listed as one of the top 100 most-cited scientists in Alzheimer's disease research and one of the top 25 scientists in free radical research. Perry is also the editor for numerous journals and is editor-in-chief for the Journal of Alzheimer's Disease. He is a fellow of the American Association for the Advancement of Sciences and past-president of the American Association of Neuropathologists.

 Scope and Content Note

The George Perry Papers include correspondence, email, grant files, committee files, drafts, laboratory notes, conference files, and slides that document his academic career and research activities primarily related to the cytopathology of Alzheimer's disease. The papers are organized into seven series: Correspondence, Grants, University Administration, Article drafts and correspondence, Professional Associations, Laboratory Notes, and Conferences.

Correspondence series includes 31 ft. of letters and 38, 839 emails written by or to Perry between 1976-2010 and is organized alphabetically by correspondent last name, journal title, or organization. Grants files include 5 ft. of planning material, proposals, and reports organized alphabetically by title. A majority of the grant files pertain to a 2004-2005 training grant in cellular and molecular aging. University Administration series consists of 2 ft. of committee minutes, agendas, reports related to committees Dr. Perry served on at Case Western Reserve School of Medicine and the University of Texas at San Antonio and are organized alphabetically by committee. Article drafts and correspondence series includes 7 ft. of drafts, correspondence, and referee reports of journal articles submitted for publication and is organized chronologically by year. Professional Associations and Conferences series include 3 ft. reference files and correspondence related to various Alzheimer and neuroscience organizations and conferernces.

This collection is housed at UTSA's HemisFair Park Campus.

 Organization of Collection

Due to size, this inventory has been divided into two finding aids which can be accessed by clicking on the following links:

I. Correspondence II. GrantsIII. University administrationIV. Article drafts and correspondenceV. Professional associationsVI. Laboratory notesVII. Conferences Access Restrictions

Some items are restricted. Contact the UTSA university archives for details.

 Usage Restrictions

The researcher assumes full responsibility for observing all copyright, property, and libel laws as they apply.

 Acquisition Information

Received as a gift from George Perry in July, 2012.

Preferred Citation

[Identification of item], George Perry Papers, UA 99.0020, University of Texas at San Antonio Libraries Special Collections.

 Index Terms Personal Names Perry, George, 1953-. Organizations University of Texas at San Antonio. Case Western Reserve University. School of Medicine. Subjects University of Texas at San Antonio. College of Sciences. University of Texas at San Antonio--Faculty. Alzheimer's disease--Research--History.Alzheimer's disease--History--20th century.Alzheimer's disease--Pathogenesis. Alzheimer's disease--Pathophysiology. Genres/Formats Correspondence. Memorandums. Local Subjects Education/EducatorsUTSA HistoryScience and Technology Inventory of the George Perry Papers Grants

Grant planning material, proposals, and reports organized alphabetically by title.

49 22 Aging changes in neuronal function and structure, National Institutes of Health AG00795-10, 1987 49 21 Alterations of the calcium regulatory system and microtubules in muscular dystrophy cells, Muscular Distrophy Association post-doctoral fellowship, 1979-1980 49 18 American Health Assistance Foundation grant, 1986-1990 31 3 American Health Assistance Foundation, 1990-2004 49 17 Amyloid precursor in Alzheimer disease, National Institutes of Health AG00415, 1988-1993 Amyloid precursor in Alzheimer disease, National Institutes of Health AG07552 49 23 1987-1990 49 19 Notice of award, 1988-1990 49 1 1993-1994 50 2 1995-1996 32 1 Anti-apoptotic activity of Alzheimer Aβ, National Insitutes of Health AG19356, 2000-2003 49 20 Calcium control of microtubule polymerization, National Institutes of Health, 1980 49 15 Cataractogenesis: crystallin synthesis in Nakano mice, National Institutes of Health post-doctoral fellowship, 1978-1979 Cellular and molecular aging training program, National Institutes of Health T32-AG00105-11 50 8 1994-2003 50 9 1994-2003 50 10 1994-2003 49 11 1994-2003 50 12 2004-2005 50 13 2004-2005 51 1 2004-2005 51 2 2004-2005 51 3 2004-2005 51 4 2004-2005 51 5 2004-2005 51 6 2004-2005 51 7 2004-2005 51 8 2004-2005 51 9 2004-2005 51 10 2004-2005 49 16 Cellular and molecular pathology of Alzheimer disease, National Institutes of Health AG08992, 1992-1993 31 1 Control of neurofilament oxidative modification, National Institutes of Health R21 NS045353, 2002 50 5 Cytoarchatectural alterations in Alzheimer disease, National Institutes of Health NS34349, 1994 31 4 Ellision Medical Foundation, 1998-2004 31 5 Human Science Frontier Program, 1995-2002 30 8 Immuno-modulation of neuronal AB and Tau, National Institutes of Health R01 AG20283, 2001 31 7 Is oxidative damage a result of metabolic abnormalitiies in Alzheimer disease?, United Mitochondrial Disease Foundation, 1999-2004 30 10 Mitochondrial dynamics in Alzheimer disease, National Institutes of Health R01 NS41789, 2001-2002 31 6 Mizutani Foundation for Glycoscience, 1994-1997 31 7 Molecular Geriatrics, 1996 Molecular pathology of Alzheimer disease, National Institutes of Health RO1 AG08155 50 6 1988 50 4 1992-1993 31 National Institutes of Health Doctor's Pioneer Award, 2004 51 11 National Institutes of Health objectives and opportunities in Alzheimer disease research, 1996 National Institutes of Health training grant 32 3 1999 32 4 1999 32 5 1999 50 3 Neurofibrillary pathology in Alzheimer disease, National Institutes of Health AG9287, 1989-1997 31 1 Neurofilament proteins are specific targets of oxidative stress, Alzheimer's Association, 1998-2005 31 4 Non-invasive assessment of oxidative stress in patients with Alzheimer's disease, Philip Morris, 1995-1997 31 2 Olfactory neurons as a model F, Panacea Pharmaceuticals, 1999-2005 31 9 Oxidative protein modifications in amyotrophic lateral sclerosis, The Amyitrophic Lateral Sclerosis Association, 1995-2002 31 3 Oxidative stress and emmetropic lateral cirrhosis, Pepper Pilot Projects in Aging Research, 1996 31 6 Oxidative stress in Autism, Presidential Research Initiative Grant Program, 2005 31 5 Philip Morris Fellowship, 2003-2004 50 7 Protein interaction in Alzheimer disease, American Health Assistance Foundation, 1990, 1993 30 9 Redox active iron in Alheimer disease, National Institutes of Health DK57785, 1999 32 2 Regulation of Aβ prooxidant activity, National Institutes of Health R01AG19374, 2000-2002 31 8 RNA oxidation: a novel biomarker for Alzheimer's disease, National Institutes of Health NIH R01 AG09287, 1999-2006 31 2 Role of metals in oxidative balance in Alzheimer disease, Alzheimer's Association, 1999-2006 Training in cellular and molecular aging 32 6 2004-2005 32 7 2004-2005 32 8 2004-2005 32 9 2004-2005 33 1 2004-2005 31 8 Yamshon Memorial Scholarship for Alzheimer Disease Research, 1996-2003 35 Grant proposals [RESTRICTED], undated University administration

Committee minutes, agendas, reports related to committees Dr. Perry served on at Case Western Reserve School of Medicine and the University of Texas at San Antonio organized alphabetically by committee.

Case Western Reserve School of Medicine 29 2 Assorted committees, 1990-2005 29 1 Bylaws Committee, 2003-2005 29 3 Case Western Reserve University 2005-2006 48 36 Committee on Fringe Benefits, 1996-1998 29 4 Committee on Qualifications and Standards for Appointments, Promotions, and Tenure, 2003-2004 29 5 Conflict of interest form, 2000-2005 29 6 Faculty activity summary form, 1995-2005 Faculty Council 48 37 Annual activity summary, 1994 48 38 Annual report, 1995 48 39 Attendance, 1994-1997 48 40 Benefits, 1994-1995 48 41 Budget, 1994-1996 48 42 Bylaws, 1992-1994 48 43 Cell Biology Department/Center, 1995 48 44 Chair appointments, 1993-1996 48 45 Committee to Review Committees, 1994-1995 48 46 Concerns, 1987-1996 48 47 Dean/Vice Provost, 1995-1996 48 48 Executive Committee, 1994-1995 48 49 Faculty Equity and Development Committee, 1993-1996 49 50 Faculty Senate, 1996 49 1 Graduate program, 1994-1995 49 2 Honor code, 1993-1995 49 3 LCME Steering Committee, 1984, 1995 49 4 Medical Research Council, 1989 49 5 Medical student graduates, 1995-1996 49 6 Minutes/agendas, 1994-1996 49 7 Nominations/elections, 1991-1995 49 8 Physical Medical Center, 1994 49 9 Promotions, 1994-1996 49 10 Psychobiology, 1995 49 11 Qualifications and standards for promotion, 1993 49 12 Scarpa affair, 1995 29 7 Tenure, 1994-1995 29 8 Faculty of Medicine agendas/minutes, 1994-1996 29 9 Inquiry Committee for Scientific Misconduct, 1997 30 1 Interdisciplinary Strategic Plan Committee, 2003-2004 Pathology 30 2 Chair Search Committee, 2000-2004 30 3 Finance Committee, 1990-1994 30 4 Self-Study Committee, 1998 30 6 President's Advisory Committee, 1996-2002 30 5 Telephone logs, 2002-2005 30 7 Undergraduate students, 1997-2000 University of Texas at San Antonio4914Strategic Planning Committee, 2006-2007Article drafts and correspondence

Drafts, correspondence, and referee reports of journal articles submitted for publication organized chronologically by year.

42 56 P4, Antibodies to neurofibrillary tangles of Alzheimer's disease raised from human and animal neurofilament fractions, Laboratory Investigation, 1983 43 2 P10, Microtubules are not altered in the dystrophic chicken, Experimental Cell Research, 1985 43 3 P9, "Electron microscopic localization of Alzheimer neurofibrillary tangle componets recognized by an antiserum to paired helical filaments," Journal of Neuropathology and Experimental Neurology, 1985 43 9 P13, "Hirano bodies: a study of their composition," Journal of Neuropathology and Experimental Neurology, 1986 43 5 P17, " Immunocytochemical properties of Alzheimer straight filaments," Journal of Neuroscience, 1987 43 6 P16, "Antibodies to neuronal cytoskeleton are elicited by Alzheimer paired helical filament fractions," Brain Research, 1987 43 8 P14, "Ubiquitin is detected in neurofibrillary tangles and senil plaques neurites of Alzheimer brain," Proceedings of the National Academy of Sciences, 1987 43 27 P27, "Lewy bodies contain componets both shared and distinct from Alzheimer neurofibrillary tangles," 1987 43 11 P24, "The antigen recognized by the monoclonal antibody Alz 50 is associated with abnormal filaments in Alzheimer disease and progressive supranuclear palsy," Annuals of Neurology, 1988 43 16 P42, "Immunohistochemical recognition of ethylnitrosourea induced rat brain microrumors by anti-lue 7 monoclonal antibody," 1988 43 26 P34, "Immunochemical properties of ubiquitin conjugates inpaired filaments of Alzheimer disease," Journal of Neurochemistry, 1988 43 18 P43, 1989 43 22 P38, "The widespread alteration of neurites in Alzheimer disease may be unrelated to amyloid deposition," 1989 43 23 P39, "Tropomyosin isoform expression in normal and neoplastic astrocytes," 1989 43 15 P50, "Tropomyosin distinguishes Lewy bodies of Parkinson disease from other neurofibrillary pathology," Brain Research, 1990 43 20 P46, "The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease," American Journal of Pathology, 1990 43 21 P47, "Immunocytochemical localization of the erythroid transporter: abundance in tissues with barrier functions," Journal of Neuroscience, 1990 43 34 P53, "Widespread sreum amyloid P immunoreactivity in cortical amyloid deposits and the neurofibrillary pathology of Alzheimer's disease and related disorders," Journal of the British Neuropathology Society, 1990 43 70 "Neuritic plaques may originate from neurofibrillary tangles," Medical Hypotheses 40:257-258, 1993, 1990 40 29 "Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease," Brain Research 558:312-314, 1991, 1991 42 54 P55, "Basic fibroblast growth factor binding is a marker," Journal of Histochemistry and Cytochemistry, 1991 44 27 "α-1-antitrypsin and α-1-antichymotrypsin are in the lesions of Alzheimer disease," Neuroreport 3:201-203, 1992, 1991 44 28 Brain Research 558:43-52, 1991, 1991 44 30 "Dementia with argyrophilic grains," Annuals of Neurology 30:853, 1991, 1991 44 32 American Journal of Tropical Medicine and Hygiene 46:391-397, 1992, 1991 41 21 "Serum proteins and the blood-brain barrier in the pathogenesis of Alzheimer's disease," Advanced Biosciences 87:153-154, 1993, 1992 44 29 "Aluminum accumulation in relation to senile plaque and neurofibrillary tangle formation in the brains of patients with renal failure," Journal of Neurological Sciences 107:210-218, 1992, 1992 44 31 Bulletin of Clinical Neurosciences 56:107-119, 1991, 1992 51 15 "Acetylcholinesterase and its association with the heparan sulphate proteoglycans in cortical amyloid plaques of Alzheimer's disease," Neuroscience 51:177-184, 1992, 1992 40 16 "Abnormal accumulation of phopholipase C-delta in filament inclusions of neurodegenerative diseases," Neuroscience Letters 159:183-186, 1993, 1993 40 17 "Immunocytochemical evidence that the β-protein precursor is an integral component of neurofibrillary tangles of Alzheimer disease," American Journal of Pathology 143:1586-1593, 1993, 1993 40 18 "Serine protease inhibitor antithrombin III and is mRNA in the pathogenesis of Alzheimer's disease," American Journal of Pathology 143:886-983, 1993, 1993 40 25 "Amyloid P component and other acute phase proteins associated with cerebellar Aβ protein deposits in Alzheimer's disease," 1993 40 27 "The role of synaptic pathology in the mechanism of dementia in Alzheimer's disease," Clinical Neuroscience 1(4), 1994, 1993 40 35 "Chondrotin sulfate proteoglycans are associated with the lesions of Alzheimer's disease," Experimental Neurology 121:149-152, 1993, 1993 41 18 "Rimmed vacuoles of inclusion body myositis and oculopharyngeal muscular dystrophy contain amyloid precursor protein and lysosomal markers," Brain Research 603:343-347, 1993, 1993 41 19 "Chondroitin sulfate proeoglycans are associated with the lesions of Alzheimer's disease," Experimental Neurology 121:149-152, 1993, 1993 41 20 "Alpha-trypsin immunoreactivity in Alzheimer disease," Biochemical and Biophysical Research Communications 193:579-584, 1993, 1993 43 33 C25, "Transformation of neurofibrillary tangles in the extracellular space," 1993 40 1 "Alteration of phospholipase C-δ protein level and specific activty in Alzheimer disease," Journal of Neurochemistry 1994, 1994 40 20 "Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer disease," American Journal of Pathology 145:42-47, 1994, 1994 40 21 "Advanced Maillard reaction end products are associated with Alzheimer disease pathology," Annuals of the New York Academy of Sciences 91:5710-5714, 1994, 1994 40 22 "Is a lewy body always a Lewy body?," Dementia in Parkinson's Disease, 1994 1994 40 26 "Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease," Biochemical and Biophysical Research Communications 209:657-663, 1995, 1994 40 31 "Chondrotin sulfate proteoglycans are a common component of neuronal inclusions and reacting astrocytes in neurodegeneratie diseases," Brain Research 656:205-209, 1994, 1994 39 68 "Amyloidosis, advanced glycation end products and Alzheimer disease," Neuroreport 6:866-868, 1995, 1995 39 69 "Glycation in neuropathies," Trends in Neurosciences 18: 1, 1995, 1995 40 4 "Diabetes mellitus and Alzheimer's disease: glycation as a biochemical link," Diabetologia 39:247, 1996, 1995 40 5 "Evidence of oxidative stress in Pick disease and corticobasal degeneration," Brain Research 1995, 1995 40 6 "Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease," Journal of Neurochemistry 65:1995, 1995 40 7 "Alterations of low molecular weight acid phosphotase protein level in Alzheimer's disease," Brain Research 699:125-129, 1995, 1995 40 9 "Dystrophic neurites define diffues as well as core-containing senile plaques in Alzheimer's disease," Neurogeneration 4:235-237, 1995, 1995 40 11 "Early AGEing and Alzheimer's," Nature 374: 316, 1995, 1995 40 43 "APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology," Neurobiology of Alzheimer's Disease, 1995, 1995 40 3 "Glial cell extracellular matrix in Alzheimer's disease," Non-Neuronal Cells in Alzheimer's Disease, 1996, 1996 40 33 "Protein modifications and interactions in Alzheimer disease," Alzheimer's Disease: Aetological Mechanisms and Therapeutic Possibilities: Springer-Verlag, 1996, 1996 40 36 "Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease," Brain Research 737:195-200, 1996, 1996 40 38 "Is Alzheimer's a disease of oxidative stress?," Alzheimer Disease Review1:63-67, 1996, 1996 40 40 "Oxidative damage in Alzheimer's," Nature 382:120-121, 1996, 1996 40 41 "Early contribution of oxidative glycation in Alzheimer disease," Neuroscience Letters 217:210-211, 1996, 1996 40 44 "Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice," Neurobiology of Aging 17:223-234, 1996 1996 40 45 "A primary role for redox imbalance and oxidative damage in neurodegenerative diseases," 3rd World Congress on Biomedical Sciences at the Virtural Conference Hall, 1996 42 36 "Alzheimer's disease, ageing, oxidative stress, and advanced glycation endproducts," Journal of Neural Transmission 105:439-461, 1998, 1997 42 43 "Neuronal oxidative stress is a common feature of Alzheimer and Parkinson diseases," Progress in Alzheimer's and Parkinson's Diseases 77-80, 1998, 1997 39 1 "Mitochondrial abnormalities: a primary basis for oxidative damage in Alzheimer's disease," Drug Development Research 46:26-33, 1999, 1998 42 22 "Striation is the dominant neuritic abnormality in Alzheimer disease," Brain Research 813:329-333, 1998, 1998 42 39 "Apoptosis and Alzheimer's disease," Science 282:1268-1269, 1998, 1998 42 41 "A suicide note from neurons in Alzheimer disease?," Nature Medicine 4: 897-898, 1998, 1998 42 46 "Altered glycosylation pattern of proteins in Alzheimer's disease," Journal of Neuropathology and Experimental Neurology 57:905-914, 1998, 1998 42 47 "Dyimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease," Free Radical Biology and Medicine 25:898-902, 1998, 1998 39 3 "Role of oxidative stress in frontotemporal dementia," Dementia and Geriatric Cognitive Disorders 10: 85-87, 1999, 1999 39 38 "Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer Disease links oxidative stress to abnormal phosphorylation," Neuroreport 10:2411-2415, 1999, 1999 39 41 "Evidence of apoptosis in Cretzfeldt-Jakob Disease?," Journal of Neuropathology and Experimental Neurology, 1999 [unpublished], 1999 41 1 "In situ oxidative catalysis by neuroibrillary tangles and senil plaques in Alzheimer disease: a central role for bound transition metals," Journal of Neurochemistry 74:270-279, 2000, 1999 44 44 "Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease," Archives of Biochemistry and Biophysics 370:236-239, 1999, 1999 44 46 Science 285:663, 1999, 1999 44 49 RNA oxidation in Alzheimer and Parkinson diseases," Journal of Anti-Aging Medicine 2:227-230, 1999, 1999 44 50 "Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model," NeuroReport 10:3229-3232, 1999, 1999 44 53 Review of Neurodegeneration Methods and Protocols, The Quarterly Review of Biology 74:510, 1999, 1999 39 6 "Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro," Redox Report 6:153-154, 2001, 2000 41 7 "Oxidative stress, antioxidants and Alzheimer Disease," Alzheimer Disease and Associated Disorders International Journal 13:1327, 1987, 2000 44 10 "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation," Journal of Cell Biology 151:847-862, 2000, 2000 44 11 "Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of donryu rats on a cholesterol-enriched diet," The Anatomical Record 259:16-25, 2000, 2000 44 12 "Prospects for noninvasive imaging of brain amyloid β in Alzheimer's disease," Annuals of the New York Academy of Sciences 903:123-128, 2000, 2000 44 13 "Arson: tracking the culprit in Alzheimer's disease," Annuals of the New York Academy of Sciences 924:35-38, 2000, 2000 44 16 "Do neurons have a choice in death?," American Journal of Pathology 59:1011-1017, 2000, 2000 44 19 "Phophorylated, but no unmodified, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2nonenal," FEBS Letters 486:270-274, 2000, 2000 44 20 "Apoptotic cell death in Alzheimer disease: fiction?," Neurobiology of Aging 22:131-146, 2001, 2000 44 21 "Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?," Mechanisms of Ageing and Development 116:169-179, 2000, 2000 44 22 "Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease," Journal of Neuropathology and Experimental Neurology 59:880-888, 2000, 2000 44 34 "Activation of NADPH oxidase in Alzheimer's disease brains," Biochemical and Biophysical Research Communications 273:5-9, 2000, 2000 44 35 "Sequestration of iron by Lewy bodies in Parkinson disease," Acta Neurologica, 2000 44 36 "Redox -active iron mediates amyloid-toxicity," Free Radical Biology and Medicine 30:447-450, 2001, 2000 44 39 "Alzheimer's disease : methods and protocols," Journal of Molecular Neuroscience 14:205, 2000, 2000 44 57 "The role of metals in neurodegenerative diseases," Cellular and Molecular Biology 46:731-741, 2000, 2000 44 59 "Evidence that the beta amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc," Journal of Biological Chemistry 275:19439-19442, 2000, 2000 45 2 "Neuroinflammatory environments promote amyloid-β deposition and posttranslational modification," Neuroinflammation, 249-266, 2003, 2000 45 5 "Melatonin reduces interleukin secretion in amyloid-β stressed mouse brain slices," Chemico-Biological Interactions 134:101-107, 2001, 2000 39 13 "Activation of MKK6, an upstream activator of p38, in Alzheimer's Disease," Journal of Neurochemistry 79:311-318, 2001, 2001 41 37 "FTD and ADHD: pathology versus pathophysiology," Neurology, Psychiatry, and Brain Research 9:137-138, 2001, 2001 41 38 "Increase of CDK5 is related to neurofibrillary pathology in progressive supranuclear palsy," Neurology 58:589-292, 2002, 2001 41 39 "Amyloid-β, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?," Neurochemistry International 40:527-531, 2002, 2001 42 30 "Formation of aberrant phosphotau fibrillar polymers in neural cultured cells," European Journal of Biochemistry 269:1484-1489, 2002, 2001 44 4 "Is oxidative damage specific?," Alzheimer Research Forum, 2002 2001 44 25 Peptides 23:1343-1350, 2002, 2001 41 40 "Call for Elan to publish Alzheimer's trial details," Nature 416:677-678, 2002, 2002 41 46 "The six degrees of Medline," The Scientist 16:12, 2002, 2002 42 10 "Dangers of the amyloid-β vaccination," Acta Neuropathologia 104:110, 2002, 2002 42 25 "Ill-fated amyloid-β vaccine," Journal of Neuroscience Research 69:285, 2002, 2002 42 28 "Causes and consequences of oxidative stress in Alzheimer's disease," Free Radical Biology and Medicine 32:1049, 2002, 2002 42 31 "The "Down's" side of mitchondria," Developmental Cell 2:255-256, 2002, 2002 43 60 Proceedings of the 11th biennial meeting of the Society for Free Radical Research International, 2002 43 63 "Prion diseases and copper metabolism," 2002 43 64 "Differential regulation of glutamate receptors in Alzheimer disease," NeuroSignal 11:282-292, 2002, 2002 43 66 "Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice," Annuals of the New York Academy of Sciences 977:45-64, 2002, 2002 43 72 "Raman microscopy of isolated senile plaque cores reveals amyloid-beta arranged as beta-sheet metalloprotein," Biochemistry 42:2768-2773, 2003, 2002 43 73 "JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer disease," Journal of Neurochemistry 85:87-93, 2003, 2002 43 74 "Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies," NeuroReport 13:2035-2039, 2002, 2002 44 8 "Effect of arachidonic acid and its oxidation products on tau phosphorylation," Journal of Neuroscience Research 71:863-870, 2003, 2002 44 51 "Harlequin and Alzheimer disease: remarkable parallels," Alzheimer Research Forum, 2002, 2002 44 52 "Specific responses to Aβ but not to the key questions," Alzheimer Research Forum, 2002, 2002 45 7 "Therapeutic potential in Alzheimer disease," Current Medicinal Chemistry 9:1605-1610, 2002, 2002 45 9 "Metals and oxidative homeostasis in Alzheimer disease," Drug Development Research 56:293-299, 2002, 2002 45 10 "Amyloid-β and tau serve antioxidant functions in the aging and Alzheimer brain," Free Radical Biology and Medicine 33:1194-1199, 2002, 2002 45 14 "Amyloid-β: a vascular sealant that protects against hemorrhage," Journal of Neuroscience Research 70:356, 2002, 2002 45 16 "Elevated luteinizing hormone expression colocalizes with neurofibrillary tangles in Alzheimer disease," Journal of Neuroscience Research 70: 514-518, 2002, 2002 45 20 "Oxidative stress increases expression and activity of BACE in NT2 neurons," Neurobiology of Disease 10:279-288, 2002, 2002 39 14 "Oxidative stress and neuronal adaptation in Alzheimer's Disease: the role of SAPK pathways," Antioxidants and Redox Signaling 5:571-576, 2003, 2003 39 15 Chapter, Alzheimer's Disease and Related Disorders: Research Advances 425-432, 2003 2003 39 19 "Amyloid-β induced toxicity of primary neurons is dependent upon differentiation associated increases in tau and cyclin-dependent kinase 5 expression," Journal of Neurochemistry 88:554-563, 2004, 2003 39 20 "Will preventing protein aggregates live up to its promise in neurodegenerative diseases?," Brain Pathology 13:630-638, 2003, 2003 39 26 "Distribution, levels, and activation of MEK1 in Alzheimer Disease," Journal of Neurochemistry 86:136-142, 2003, 2003 39 31 "X-ray contrast media induces aortic endothelial damage, which can be prevented with prior heparin treatment," Journal of Submicroscopic Cytology and Pathology 35:253-266, 2003, 2003 41 55 "Mitogen-activated protein kinase pathways in nervous system and Alzheimer disease," Frontiers in Neurodegenerative Disorders and Aging 189-1999, 2004, 2003 41 56 "Neuronal cell cycle re-entry: a doomed journey in Alzheimer disease?," Frontiers in Neurodegenerative Disorders and Aging 200-206, 2004, 2003 42 11 "Cerebral amyloid angiopathy: major contributor of decoratove response to Alzheimer disease pathogenesis," Neurobiology of Aging 25: 599-602, 2004, 2003 42 21 "Oxidative stress in Alzheimer disease: the earliest cytological and biochemical feature," Molecular Neurobiology of Alzheimer Disease and Related Disorders 164-171, 2004, 2003 42 52 "Homoxysteine and Alzheimer disease: a modifiable risk?," Free Radical Biology and Medicine 36:1471-1475, 2004, 2003 43 57 "Tipping the apoptotic balance in Alzheimer disease: the abortosis concept," Cell Biochemistry and Biophysics 39:249-255, 2003, 2003 43 58 "The olfactory system in Alzheimer disease shows increased oxidative damage," Acta Neuropathologica 106:552-556, 2003, 2003 43 65 Letter to the editor, Science 299:1014, 2003, 2003 43 71 "Ectopic localization of phosphorylated histone3 in Alzheimer disease: a mitotic catastrophe," Act Neurologica 105:524-528, 2003, 2003 39 52 "Concealment of epitope by reduction and alkylation in prion protein," Biochemical and Biophysical Research Communications 326:652-650, 2005, 2004 39 55 Proceedings of the XII biennial meeting of the Society for Free Radical Research Society, 2004, 2004 39 58 Biochimica et Biophysica Acta 1740:472-478, 2005, 2004 39 61 "Drug therapy in Alzheimer's Disease," New England Journal of Medicine 351:1911, 2004, 2004 39 62 "BACE-1 up-regulation induced by 4-hydroxynonenalis is mediated by stress activated protein kinases pathways," Journal of Neurochemistry 92:628-636, 2005, 2004 39 63 "Brain metabolic alterations are early signs in Alzheimer disease pathophysiology," Research and Practice in Alzheimer's Disease and Cognitive Decline Special Issue: 61-65, 2005, 2004 39 65 "Oxidative imbalance in Alzheimer disease," Molecular Biology 31:205-218, 2005, 2004 39 66 "Chronological primacy of oxidative stress in Alzheimer disease," Neurobiology of Aging 26:579-580, 2005, 2004 41 24 "Soluble amyloid B-protein is increased in frontotemporal dementia with tau gene mutations," Journal of Alzheimer's Disease 6:45-51, 2004, 2004 41 29 "Abberant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease," Acta Neuropathologica 107:365-371, 2004, 2004 41 30 "Different perspectives on the amyloid-β cascade hypothesis," Journal of Alzheimer's Disease 6:137-145, 2004, 2004 41 31 "Therapeutic potential of oxidant mechanisms Alzheimer's disease," Expert Review of Neurotherapeutics 4:995-1004, 2004, 2004 41 43 "Mitotic and gender parallels in Alzheimer disease: therapeutic opportunities," Current Drug Targets 5:559-563, 2004, 2004 41 52 "Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-β precursor protein and amyloid-β deposition," Journal of Biological Chemistry 279:20539-20545, 2004, 2004 42 5 "Amyloid-β and Alzheimer disease: a warning," The Scientist 8: 10, 26, 2004, 2004 42 7 "Mitochondrial failures in Alzheimer disease," American Journal of Alzheimer's Disease and Other Dementia 19:345-352, 2004, 2004 42 12 "Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease," Current Drug Targets 3:281-285, 2004, 2004 42 17 "Staying connected: synapes in Alzheimer disease," American Journal of Pathology 165:1461-1464, 2004, 2004 42 18 "Alzheimer's disease: a two hits wonder?," Alzheimer Research Forum, 2004, 2004 42 19 "Pathology is not necessarily pathogenic," Science of Aging Knowledge Environment Bulletin Board, 2004-10-29, 2004 42 51 "Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease," Neurological Research 25:665-674, 2003, 2004 43 45 Mitogen-and strerss-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease," Journal of Neuroscience Research 79:554-560, 2005, 2004 43 48 "Neurotoxic-dopamine-quinone facilitates the assembly of tau into fibrillary ploymers," Molecular and Cellular Biochemistry 278:203-212, 2005, 2004 39 23 "Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis," Annuals of the New York Academy of Sciences 1052:201-209, 2005, 2005 39 45 "Carosine: a versatile antioxidant and antiglycating agent," Science of Aging Knowledge Environment 18:pe12, 2005, 2005 39 53 "Amyloid-β in Alzheimer Disease: the horse or the cart? Pathogenic or protective?," Journal of Experimental Pathology 86:133-138, 2005, 2005 39 56 Chemical Research in Toxicology 18:1219-1231, 2005, 2005 43 1 P2, "Characterization of a Ca2+-stimulated lipid oxidizing system in the sea urchin egg," "Fertilization stimulates lipid oxidation in the sea urchin egg," Developmental Biology, 1981-1984 43 4 P8, "Alzheimer's paired helical filaments contain cytoskeletal componets," Proceedings of the National Academy of Sciences, 1984-1985 43 7 P15, "Filaments of Pick's bodies contain altered cytoskeletal elements," American Journal of Pathology, 1986-1987 43 10 P25, "Amyloid precursor protein is in senile plaques of Alzheimer disease," The Lancet ii:746, 1988, 1987-1988 43 12 P23,"Arachidonic acid metabolism in ascidia ceratodes eggs: role g lipid peroxidation," Comparative Biochemistry and Physiology, 1987-1988 43 13 P22, "Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative disease," Proceedings of the National Academy of Sciences, 1987-1988 43 31 P21, "Influence of neuronal location on the antigenic properties of neurofibrillary tangles," Annuals of Neurology, 1987-1988 43 30 P20, "Paramyosin and actin in the schistosomal tegument: role in protective immunity," Nature, 1987-1989 43 29 P19, "Role of calmodulin in plasmodium falciparum: implications for erythrocyte invasion by the merozoite," European Journal of Cell Biology, 1987-1990 43 24 P30, "Immunoaffinity demonstration that paired helical filaments of Alzheimer disease sared epitopes with neurofilaments, MAP2 and tau," Brain Research, 1988-1989 43 28 P28, "(LI-8555) Ubiquitin is present on the cytokeratin intermediate filaments and mallory bodies of hepatocytes," Laboratory Investigation, 1988-1989 42 53 P54, "Neuropil threads of Alzheimer disease show a marked alteration of the normal cytoskeleton," Journal of Neuroscience 463-488, 1991, 1988-1991 43 54 "Filaments of lewy bodies contain insuluble cytoskeletal elements," American Journal of Pathology 140:809-822, 1992, 1988-1992 43 17 P44, "Glucose transporters are abundant in cells with "occluding" junctions at the bloody-eye barriers," Proceedings of the National Academy of Sciences, 1989-1990 43 19 P45, "Immunochemical demonstration of tropomysin in the neurofibrillary of Alzheimer disease," American Journal of Pathology, 1989-1990 43 14 P56, "Demonstration of a novel neurofilament associated antigen with neurofibrillary pathology of Alzheimer and related diseases," Brain Research, 1989-1991 42 55 C23, "Alzheimer disease," Neuroscience Year, 1990-1991 43 36 P51, "Abnormal tau-reactive filaments in olfactory mucosa in biopsy specimens of patients with probable Alzheimer's disease," 1990-1991 43 53 "Association of heparan sulfate proteoglycan with the intraneuronal neurofibrillary pathology of Alzheimer disease," Journal of Neuroscience 11:3679-2683, 1991, 1990-1991 43 69 "Senile plaques neurites in Alzheimer disease accumulate amyloid precursor protein," Proceedings of the National Academy of Sciences 88:7552-7556, 1991, 1990-1991 43 52 "Neurofibrillary tangles contain β-amyloid precursor protein, β-protein and are associated with dystrophic neurites," Brain Research 560:303-305, 1991, 1990-1992 44 26 "Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease," American Journal of Pathology 140:947-958, 1992, 1990-1992 41 22 "The neuronal cytoskeleton," Neurology 42:1130, 1993, 1991-1992 43 32 P68, "Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases," Brain Research, 1991-1992 43 39 P72, "Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal and aged Alzheimer disease brains," Acta Neuropathologica 85:233-240, 1992, 1991-1992 44 17 "Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer disease," American Journal of Pathology 140:283-290, 1992, 1991-1992 41 3 "Barrier properties of testis microvessels," Proceedings of the National Academy of Sciences 90, 1993, 1991-1993 41 5 "Quantitative solubilzation and analysis of SDS-insoluble paired helical filaments from Alzheimer disease," 1991-1996 40 19 "Accumulation of the β amyloid precursor protein at sites of ischemic injury in rat brain," Journal of Neuroscience 13:3136-3142, 1993, 1992-1993 41 4 "Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease," Brain Research 623:142-146, 1993, 1992-1993 43 35 P71, "Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities," Brain Research, 1992-1993 43 37 P73, "Neuritic plaques in Alzheimer disease originate from neurofibrillary tangles," Medical Hypotheses, 1992-1993 43 38 P74, "Ontogeny of the erythroid/HepG2-type glucose transporter (GLUT-1) in the rat nervous system," Developmental Brain Research 72:41-49, 1993, 1992-1993 39 73 "α1-trypsin interaction with the senile plaques of Alzheimer disease is mediated by β-protein precursor," Molecular and Chemical Neuropathology 27:145-154, 1996, 1993-1994 40 2 "Advanced Maillard reaction end products are associated with Alzheimer disease pathology," Proceedings of the National Academy of Sciences 91:5710-5714, 1994, 1993-1994 40 12 "AJP 93-797 heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer disease," American Journal of Pathology 145:42-47, 1994, 1993-1994 40 30 "Alzheimer disease: an imbalance of proteolytic regulation?," Medical Hypotheses 42:277-279, 1994, 1993-1994 40 32 "Characterization of the association of phopholipase C-δ with Alzheimer neurofibrillary tangles," Brain Research 669:217-224, 1995, 1993-1994 39 71 "Elastase is associated with the neurofibrillary pathology of Alzheimer disease: a putative link between proteolytic imbalance and oxidative stress," Restorative Neurology and Neurosciences 9:213-217, 1996, 1993-1996 40 37 "Alzheimer disease: protein interaction and oxidative stress," Boletín de Estudios Médicos y Biologicos 44:5-10, 1996, 1993-1996 39 70 "Ultrastructural localization of heme oxygenase-1 to the neurofibrillary pathology of Alzheimer disease," Molecular and Chemical Neuropathology 28:41-48, 1996, 1994-1995 39 72 "Free radical damage, iron, and Alzheimer's disease," Journal of Neurological Sciences 4769,1995, 1994-1995 40 8 Neurology 45:1764-1765, 1995, 1994-1995 40 10 "Beta PP and tau interaction: a possible link between amyloid and tangle formation in Alzheimer's disease," American Journal of Pathology 148:79-87, 1996, 1994-1995 40 14 "Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer disease," Journal of Neurochemistry 64:2660-2666, 1995, 1994-1995 40 15 "Senile plaques and neurofibrillary tangles: the concurrent lesions of Alzheimer's disease," Neurobiology of Aging 16: 1995, 1994-1995 40 23 "Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease," Acta Neuropathologica 89:291-295, 1995, 1994-1995 40 24 "Tau binding to a conformation-dependent sequence of β-protein precursor in Alzheimer disease," 1994-1995 40 28 "The role of oxidative stress in Alzheimer disease," Trends in Neurosciences 18:172-176, 1995, 1994-1995 41 2 "Plasma membrane abnormalities of dystrophic neutites in senile plaques of Alzheimer disease" and "Filament hetergeneity within the dystrophic neurites of senile plaques in Alzheimer disease," Acta Neuropathologica, 1994-1995 40 13 Dawborn, D. and Allan, Neurobiology of Alzheimer's Disease , 1995-1996 40 34 "Oxidative stress and protein modification in neurodegenerative disease," Free Radicals in Brain Physiology and Disorders, 289-292, 1996, 1995-1996 40 39 "α-calcium-calmodulin-dependent kinase II is associated with paried helical filaments of Alzheimer's disease," Journal of Neuropathology and Experimental Neurology 55:954-963, 1996, 1995-1996 40 42 "Diseases of the aging brain: the role of oxidative stress," The Physician's Newsletter 1:3-4, 1996, 1995-1996 42 40 "Oxidative damage: an early and central event in the pathogenesis of Alzheimer disease," Neurochemical Markers of Degenerative Disease and Drug Addiction, 93-110, 1998, 1996-1998 39 4 "Alzheimer's Disease," Encyclopedia of Neuroscience, 1998 1996-1999 42 42 "Oxidative damage in Alzheimer's disease," Neurogerontology and Neurogeriatrics 2:57-62, 1998, 1996-1999 42 16 "Advanced lipid peroxidation end-products in Alexander's disease," Brain Research 1998, 1997-1998 42 32 "Is oxidative damage central to the pathogenesis of Alzheimer disease?," Acta Neurologica Belgica 98:175-179, 1998, 1997-1998 42 33 "Cerebrovascular muscle atrophy is a feature of Alzheimer's disease," Brain Research 791:63-66, 1998, 1997-1998 42 34 "The case for vascular abnormalities in Alzheimer's disease," Current Research in Alzheimer's Disease 3:181-186, 1998, 1997-1998 42 35 "Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine," The Journal of Histochemistry and Cytochemistry 46:731-735, 1998, 1997-1998 42 38 "Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress," Journal of Neurochemistry 70:2212-2215, 1998, 1997-1998 42 44 "Primary involvement of oxidative damage and redox imbalance in Alzheimer and other neurodegenerative diseases," Redox Regulation of Cell Signaling and Its Clinical Application, 1998, 1997-1998 44 40 "Alexander disease: Alzheimer disease of the developing brain?," Alzheimer Disease and Associated Disorders 13:232-235, 1999, 1997-2000 45 1 "In Alzheimer disease, heme oxygenase is coincident with Alz50, an epitope of τ induced by 4-hydroxy-2nonenal modification," Journal of Neurochemistry 75:1234-1241, 2000, 1997-2000 39 2 "Redox metals and neurodegenerative disease," Current Opinion in Chemical Biology 3: 220-225, 1999, 1998-1999 39 35 Biocongugate Chemistry 10:112-118, 1999, 1998-1999 39 36 "Quinone reductase NQO1, a sensative redox indicator, is selectively increased in Alzheimer disease," Redox Report 4:23-27, 1999, 1998-1999 39 37 Neuroscience 89:687-700, 1999, 1998-1999 39 39 Genetic evidence for oxidative stress in Alzheimer's Disease," Neuroreport 10:1355-1357, 1999, 1998-1999 39 40 "Es la lesion producida por oxidacion una parte central en la patogenesis de la enfermedad de Alzheimer?," Neurologia 1728.0 1999, 1998-1999 39 42 "Is increased redox-active iron in Alzheimer Disease a failure of the copper-binding protein ceruloplasmin?," Free Radical Biology and Medicine 26:1508-1512, 1999, 1998-1999 39 43 "Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA," American Journal of Pathology 154:1423-1429, 1999, 1998-1999 42 37 "What are the facts and artifacts of the pathogenesis and etiology of Alzheimer disease," Journal of Chemical Neuroanatomy 16:35-41, 1998, 1998-1999 42 45 "RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease," Journal of Neuoscience 19:1959-1964, 1999, 1998-1999 44 45 "Neuronal oxidative damage in Alzheimer disease may be brought about by a fundamental shift in redox balance and oxidative metabolism," Recent Research Developments in Neurochemistry 2:277-285, 1999, 1998-1999 44 47 "In situ methods for detection and localization of markers of oxidative stress: application in the study of neurodegenerative disorders," Methods in Enzymology 309:133-152, 1999, 1998-1999 41 8 "Overexpression of heme oxygenase-1 in neuronal cells: possible interaction with tau," Journal of Biological Chemistry 275:5395-5399, 2000, 1998-2000 41 17 "Molecular and cellular aspects of oxidative damage in Alzheimer's disease," Free Radicals in Brain Pathophysiology, 2000, 1998-2000 44 56 "Oxidative stress in Alzheimer disease," Biochimica et Biophysica Acta 1502:139-144, 2000, 1998-2000 44 58 "What oxidative stress tells us about therapuetic targets for Alzheimer's disease," Current Opinion in Central and Peripheral Nervous System Investigational Drugs 2:423-426, 2000, 1998-2000 43 56 Diabetes 50:2792-2808, 2001, 1998-2001 41 6 "Vascular pathology in Alzheimer's Disease," Neurobiology of Aging 21:357-361, 2000, 1999-2000 41 9 Lipoperooxidation is selectively involved in progressive supranuclear palsy," Journal of Neuropathology and Experimental Neurology 59:393-397, 2000, 1999-2000 41 10 "Morphological features of regeneration of rabbit aortic endothelium after cryoinduced vascular damage," Journal of Submicroscopic Cytology and Pathology 31:495-502, 1999, 1999-2000 41 11 "Amyloid-β junkies," The Lancet 355:757, 2000, 1999-2000 41 12 "Oxidative damge in Alzheimer's disease: the metabolic dimension," International Journal of Developmental Neuroscience 18:417-421, 2000, 1999-2000 41 13 "Promise and pitfalls of therapeutics to modify oxidant balance in chronic disease," IDrugs 3:371-372, 2000, 1999-2000 41 14 "Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome," Annuals of the New York Academy of Sciences 893:362-364, 1999, 1999-2000 41 15 "Histochemical and immunocytochemical approaches to the study of oxidative stress," Clinical Chemistry Laboratory Medicine 38:93-97, 2000, 1999-2000 41 16 "How important is oxidative damage? Lessons from Alzheimer's disease," Free Radical Biology and Medicine 28:831-834, 2000, 1999-2000 44 3 "Neuronal oxidative stress precedes amyloid-β deposition in Down Syndrome," Journal of Neuropathology and Experimental Neurology 59, 2000, 1999-2000 44 14 "Metabolic metallic, and mitotic sources of oxidative stress in Alzheimer disease," Antioxidants and Redox Signaling 2:413-420, 2000, 1999-2000 44 15 "Protein disulfide isomerase in Alzheimer disease," Antioxidants and Redox Signaling 2:485-489, 2000, 1999-2000 44 48 "Antioxidant reversal of oxidative stress-induced memory deficits," Neuroreport 10:I, 1999, 1999-2000 39 10 "Oxidative damage is an early event in Alzheimer Disease," Journal of Neuropathology and Experimental Neurology 60:759-767, 2001, 1999-2001 39 12 "Induction of NADPH cytochrome P450 reductase by the Alzheimer amyloid β-protein," Journal of Neurochemistry 78:121-128, 2001, 1999-2001 44 2 "Amyloidosis in Alzheimer disease," Les Amyloses 513-518, 2000, 1999-2001 44 37 "Homeostatic control of oxidant balance in Alzheimer disease," Recent Research Developments in Neurochemistry 3:157-159, 2000, 1999-2001 44 42 Mitchondrial abnormalities in Alzheimer's disease," Journal of Neuroscience 21:3017-3023, 2001, 1999-2001 42 24 "Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium," Journal of Submicroscopic Cytology and Pathology 34:37-50, 2002, 1999-2002 42 8 "In situ localization of non-enzymatic peroxidase-like activity of tissue -bound transition metals,"Current Protocols in Toxicology, Vol. 2, 17.4.1-17.4.8, 2004, 1999-2004 39 5 "Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease," NeuroReport 12:1277-1280, 2001, 2000-2001 39 8 "Differential activation of neuronal erk, jnk/sapk and p38 in Alzheimer's Disease: the two-hit hypothesis," Mechanisms of Aging and Development 123:39-46, 2001, 2000-2001 39 9 "The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro," Journal of Submicroscopic Cytology and Pathology 33:141-149, 2001, 2000-2001 41 49 "Apoptotic and oxidative indicators in Alzheimer's disease," Neuromethods 37:225-246, 2002, 2000-2001 42 3 "The role of oxidative stress in the pathphysiology of cerebrovascular lesions in Alzheimer's disease," Brain Pathology 12:21-35, 2002, 2000-2001 43 55 "Induction of atherosclerotic lesions is associated with increased immunoreactivities of NADPH-diaphorase, inducible nitric oxide synthases (NOS) and endothelin-1 (ET-1) in intimal cells of thoracic aorta in Watanabe rabbits," Experimental and Molecular Pathology 71:40-54, 2001, 2000-2001 43 68 "Factors controlling oxidative damage in Alzheimer's disease," Free Radicals in Chemistry, Biology, and Medicine 417-423, 2000, 2000-2001 44 5 "Mechanisms by which metals promote events connected to neurodegenerative diseases," Brain Research Bulletin 55:125-132, 2001, 2000-2001 44 6 "Oxidative imbalance is a major feature of Alzheimer disease," Current Topics in Biochemical Research 3:151-156, 2000, 2000-2001 44 18 "Erythrocyte, plasma and serum antioxidant activities in untreated toxic mulitnodular goiter patients," Free Radical Biology and Medicine 30:665-667, 2001, 2000-2001 44 23 "Activation and redistribution of JNK/SAPK in Degenerating Neurons in Alzheimer disease," Journal of Neurochemistry 76:435-441, 2001, 2000-2001 44 24 "Nitrotyrosine: a protective response?," Science 291:595-596, 2001, 2000-2001 44 33 "Abortive apoptosis in Alzheimer disease," Acta Neurologica 101:305-310, 2001, 2000-2001 44 38 "Research evaluation," The Scientist 15: 1, 2001, 2000-2001 44 41 "Active glycation in neurofibrillary pathology of Alzheimer disease: Ne-(carboxymethyl) lysine and hexitol-lysine," Free Radical Biology and Medicine 31:175-180, 2001, 2000-2001 45 3 "Hibernation, a model of neuroprotection in traumatic brain injury," American Journal of Pathology 158:2145-2151, 2001, 2000-2001 45 4 "Oxidative damage and antioxidant responses in Alzheimer disease," Alzheimer Disease: Advances in Etiology, Pathogenesis and Therapeutics, 2001 2000-2001 39 11 "High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal," Journal of Biological Chemistry 277:4644-4648, 2002, 2000-2002 42 2 "The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications," CNS Drugs 16:339-352, 2002, 2000-2002 42 27 "Melatonin exhibits antioxidant properties in a mouse brain slice model of excitotoxicity," International Journal of Circumpolar Health 61:32-40, 2002, 2000-2002 43 67 "Neurodegenerative disease: role of free radical damage," Research and Practice in Alzheimer's Disease 6:287-290, 2002, 2000-2002 44 7 "Microtubule reduction in Alzheimer disease is independent of PHF formation," American Journal of Pathology 162:1623-1627, 2003, 2000-2002 45 11 "Is oxidative damage the fundamental pathogenic mechanism of Alzheimer and other neurodegenerative diseases?," Free Radical Biology and Medicine 33:1475-1479, 2002, 2000-2002 45 17 "Labeling of cerebral amyloid-β deposits in vivo using intranasal bFGF and SAP component," Journal of Nuclear Medicine 43:1044-1061, 2002, 2000-2002 41 23 Exercise and Disease, 7-16, 2003, 2000-2003 41 27 "Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease," Journal of Neuroscience Research 75:698-703, 2004, 2000-2004 41 51 "Neuroprotective properties of Bcl-w in Alzheimer's disease," Journal of Neurochemistry 279:20539-20545, 2004, 2000-2004 39 67 "Oxidative damage and Alzheimer Disease: are antioxidant therapies useful?," Drug News and Perspectives 18:13-19, 2005, 2000-2005 39 7 "Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem lewy bodies," Neuroscience Letters 319: 28-35, 2002, 2001-2002 41 35 "Involvement of Maillard reactions in Alzheimer's disease," Neurotox 4:191-209, 2002, 2001-2002 41 36 "Is Alzheimer's disease a mitochondrial disorder," The Neuroscientist 8:489-496, 2002, 2001-2002 41 41 "Systematic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy," Neurobiology of Disease 9:244-248, 2002, 2001-2002 41 42 "Oxidative damage to nucleic acids in human prion disease," Neurobiology of Disease 9:275-281, 2002, 2001-2002 41 47 "Oxidant and antioxidant responses in Alzheimer disease," Recent Research Developments in Biophysics and Biochemistry 1:35-41, 2001, 2001-2002 41 48 "The mitochondrial common deletion in Parkinson's disease and related movement disorders," Parkinsonism and Related Disorders 8:165-170, 2002, 2001-2002 42 9 "Will anti-inflammatories fulfill their promise?," Alzheimer's Research Forum, 2001-2002, 2001-2002 42 23 "Predicting the failure of amyloid-β vaccine," The Lancet 359:1864-1865, 2002, 2001-2002 42 26 "Reactive oxygen: its sources and significance in Alzheimer disease," Journal of Neural Transmission 62:67-73, 2002, 2001-2002 42 29 "Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins," The FASEB Journal 10.1096/fj.01-0530fje, 2002-02-25, 2001-2002 43 61 "Amyloid-β: a (life) preserver for the brain," Neurobiology of Aging 23:1097-1099, 2002, 2001-2002 44 43 "The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer disease?," Peptides 23:1333-1341, 2002, 2001-2002 44 54 "Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease," Biometals 16:77-81, 2003, 2001-2002 44 55 "Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response," Comparative Biochemistry and Physiology 133:507-513, 2002, 2001-2002 45 6 "Role of the antioxidant ascorbate in hibernation and warming from hibernation," Comparative Biochemistry and Physiology 133:483-492, 2002, 2001-2002 45 8 "Iron: a pathological mediator of Alzheimer's disease?," Developmental Neuroscience 24:184-187, 2002, 2001-2002 45 12 "Role of heme catabolism in neurodegenerative diseases," Physiology/Pathology of Heme Oxygenase, 135-143, 2002, 2001-2002 45 13 "Alzheimer disease and oxidative stress," Journal of Biomedicine and Biotechnology 2:120-123, 2002, 2001-2002 45 15 "Role of mitchondrial dysfunction in Alzheimer's disease," Journal of Neuroscience Research 70:357-360, 2002, 2001-2002 45 18 "Neuronal survival and death in Alzheimer disease," Mapping the Progress of Alzheimer's and Parkinson's Disease, 49-57, 2002, 2001-2002 45 19 "The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress and tau," Neurobiology of Aging 23:855-859, 2002, 2001-2002 39 17 "The role of oxidative mechanisms in neurodegenerative diseases," Neurodegeneration 8-10, 2003 2001-2003 39 21 "Metal homeostatsis relates to oxidative stress in Alzheimer's Disease," Redox Genome Interactions in Health and Disease 425-437, 2004, 2001-2003 39 22 "Role of vascular hypoperfusion induced oxidative stress and mitocondria failure in the pathogenesis of Alzheimer Disease," Neurotoxicity Research 5:385-390, 2003, 2001-2003 39 29 "Copper mediates dityrsine crosslinking of Alzheimer's amyloid-β," Biochemistry 43:560-568, 2004, 2001-2003 43 40 "Microtubule reduction in Alzheimer disease is independent of PHF formation," American Journal of Pathology 162:1623-1627, 2003, 2001-2003 44 9 "Role of high mobility group protein-1 (HMG-1) in senile plaque homeostasis in Alzheimer's disease," Biochemical and Biophysical Research Communications 301:699-703, 2003, 2001-2003 39 16 "Metal-catalyzed redox activity in neurodegenerative diseases," Metal Ions and Neurodegenerative Disorders 1-14, 2003, 2002-2003 39 18 "Amyloids, aggregates and neuronal inclusions," Current Medicinal Chemistry 3:293-298, 2003, 2002-2003 39 25 "Hydroxynonenal , toxic carbonyls, and Alzheimer Disease," Molecular Aspects of Medicine 24:305-313, 2003, 2002-2003 39 27 "Increased p27, an essential component of cell cycle control, Alzheimer's Disease," Aging Cell 2:105-110, 2003, 2002-2003 39 28 "Oxidative stress and predominant Aβ 42(43) deposition in myopathies with rimmed vacuoles, Acta Neuropathologica 105:581-585, 2003, 2002-2003 39 30 "A metabolic basis for Alzheimer Disease," Neurochemistry Research 28:1549-1552, 2003, 2002-2003 39 32 Redox Report 8:129-133, 2003, 2002-2003 39 33 "4-Hydroxynonenal contributes to NGF withdrawal induced neuronal apoptosis," Journal of Neurochemistry 85:999-1005, 2003, 2002-2003 39 34 "Functional implications of antiestrogen induction of quinone reductase: inhibition of estogen-induced DNA damage," Molecular Endocrinology 17:1344-1355, 2003, 2002-2003 39 44 "Amyloid-β the good, the bad, and the ugly," Brain Research Review 43:1-16, 2003, 2002-2003 42 4 "Hypoperfusion, mitochondria failure, oxidative stress, and Alzheimer disease," Journal of Biomedicine and Biotechnology 2003:162-163, 2003, 2002-2003 43 59 "Apoptotic promoters and inhibitors in Alzheimer disease: who wins out?," Progress in Neuropsychopharmacology and Biological Psychiatry 27:251-254, 2003, 2002-2003 43 62 "The role of MAPK pathways in Alzheimer disease," NeuroSignals 11:270-281, 2002, 2002-2003 43 75 "Sources contributing to the initiation and propagation of oxidative stress in Alzheimer disease," Proceedings of the Indian National Academy of Sciences 69:251-260, 2003, 2002-2003 44 1 "Vascular hypoperfusion, mitochondria failure and oxidative stress in Alzheimer disease," Proceedings of the Indian National Academy of Sciences 69:209-238, 2003, 2002-2003 39 24 "La función del estrés oxidativo en la patogénesis de la enfermedad de Alzheimer/The role of oxidative stress in the pathogenesis of Alzheimer's Disease," Revista Chilena de Neuro-Psiquiatria 41:47-52, 2003, 2002-2004 41 25 "Increased neuronal RNA oxidation in familial Alzheimer disease," Neurobiology of Disease 17:108-113, 2004, 2002-2004 42 1 "The role of leutinzing hormone in the pathogenesis of Alzheimer disease," Principles of Gender Specific Medicine, 1234-1237, 2004, 2002-2004 42 48 "When hypotheses dominate: established ideas can strangle the assessment of valid alternatives," The Scientist 18: 6, 2004, 2002-2004 42 49 "Neurofilament proteins in neurodegenerative diseases," Cellular and Molecular Life Sciences 61:3057-3075, 2004, 2002-2004 43 44 "Is tau a potential therapeutic target in neurodegenerative disorders?," Trends in Molecular Medicine 11: 164-169, 2005, 2002-2004 39 46 "Pathobiology of familial hypercholesterolemic atherosclerosis," International Journal of Experimental Pathology 36:225-240, 2004, 2003-2004 39 57 "Oxidative stress mechanisms and potential therapeutics in Alzheimer Disease," Journal of Neural Transmission 112:921-932, 2005 2003-2004 39 64 "Mitochondrial DNA deletions in atherosclerolic hypoperfused brain microvessels as a primary target for the development of Alzheimer's Disease," Journal of Neurological Science 229:285-292, 2005, 2003-2004 41 26 "Challenging the amyloid cascade hypothesis: senile plaques and amyloid-β as protective adaptations to Alzheimer disease," Annuals of the New York Academy of Sciences 1019:1-4, 2004, 2003-2004 41 28 "Oxidative stress and redox-active iron in Alzheimer's disease," Annuals of the New York Academy of Sciences 1012:179-182, 2004, 2003-2004 41 32 Oxidative stress mechanisms and potential therapeutic modalities in Alzheimer disease," Medicinal Chemistry Reviews 1:19-23, 2004, 2003-2004 41 33 "Alzheimer's disease: the two-hit hypothesis," The Lancet Neurology 3:219-226, 2004, 2003-2004 41 34 "Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients," Aging Cell 3:41-44, 2004, 2003-2004 41 44 "Accelerated α-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells," Brain Research 1013:51-59, 2004, 2003-2004 41 50 "Regulation of glycogen synthase kinase-3 [beta] by products of lipid perioxidation in neuroblastoma cells," Journal of Neurochemistry 89:1224-1232, 2004, 2003-2004 41 53 "Alzheimer's disease," Encyclopedia of Neuroscience, 2004, 2003-2004 41 54 "Heme catabolism and heme oxygenase in neurodegeneration disease," Antioxidants and Redox Signaling 6:888-894, 2004, 2003-2004 41 57 "Eat less, eat better, and live longer: does it work and is it worth it? The role of diet in aging and disease," The Fountain of Youth: Cultural, Scientific, and Ethical Perspectives on a Biomedical Goal, 201-227, 2004, 2003-2004 42 13 "The role of redox active iron in Alzheimer disease," Current Medical Literature-Neurology 20:25-30, 2004, 2003-2004 42 14 "The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease," In Vivo 18:325-334, 2004, 2003-2004 42 15 "Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species," Journal of Alzheimer's Disease 6:165-169, 2004, 2003-2004 42 50 "Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease," Ageing Research Reviews 3:319-326, 2004, 2003-2004 43 41 "Tau modifiers as therapeutic targets for Alzheimer's disease," Biochimica et Biophysica 1739:211-215, 2005, 2003-2004 43 51 "Alzheimer-specific epitopes of tau represent lipid perioxidation induced conformations," Free Radical Biology and Medicine 38:746-754, 2005, 2003-2004 39 50 Retinoic acid isomers protect hippocampal neurons from amyloid-β induced neurodegeneration," Neurotoxicity Research 7:243-250, 2005, 2003-2005 39 54 "Gender differences in Alzheimer Disease: the role of luteinizing hormone in pathogenesis," Alzheimer's Disease and Associated Disorders 19:95-99, 2005, 2003-2005 41 45 "Oxidative stress signaling in Alzheimer disease," Brain Research 1000:32-39, 2004, 2003-2005 43 46 "Evidence for the role of gonadotropin hormones in the development of Alzheimer disease," Cellular and Molecular Life Sciences 62:293-298, 2005, 2003-2005 39 47 "Ferric cycle activity and Alzheimer Disease," Current Neurovascular Research 2:261-267, 2005, 2004-2005 39 48 "Involvement of complex carbohydrate chemistry in Alzheimer's disease," Medical Hypotheses and Research 2:393-400, 2005, 2004-2005 39 49 "Mitochondria and Alzheimer's Disease: A powerful link," Mitochondrial News 9:1, 8, 15, 2004, 2004-2005 39 51 "Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron," Journal of Biological Chemistry 280:20978-20986, 2005, 2004-2005 39 59 "The MAPKs are differentially mediated in artic ground squirrels during hibernation," Journal of Neuroscience Research 80:862-868, 2005, 2004-2005 39 60 "Oxidative stress neurodegeneration," Annuals of the New York Academy of Sciences 1043:1-8, 2005, 2004-2005 42 6 "Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease," Journal of Mitochondrion 4: 649-663, 2004, 2004-2005 42 20 "Alzheimer disease: oxidative stress and homeostatic regulation," Revista de Faculdade de Medicina de Lisboa 9:455-460, 2004, 2004-2005 43 42 "Therapeutic opportunities in Alzheimer disease," Current Medicinal Chemistry 12:1137-1147, 2005, 2004-2005 43 43 "A second look into the oxidant mechanisms in Alzheimer's disease," Current Neurovascular Research 2:179-184, 2005, 2004-2005 43 47 "Chitin in Alzheimer disease brains," Current Alzheimer Research 2:419-423, 2005, 2004-2005 43 49 "Oxidative stress: the old enemy in Alzheimer's disease pathophysiology," Current Alzheimer Research 2:403-408, 2005, 2004-2005 43 50 "Alzheimer's disease and oxidative stress: the old program remains unsolved," Current Medicinal Chemistry 5:51-62, 2005, 2004-2005 43 25 P33, undated 36-37 Referee reports [RESTRICTED], undated Professional associations

Correspondence and subject files related to professional associations organized alphabetically by title.

34 1 American Association for the Advancement of Science, 1997-2006 34 2 American Association of Neuropathologists, 1985-2003 34 3 American Institute of Biological Sciences, 1999 34 4 American Men and Women of Science, 1988-2002 34 5 American Society of Cell Biology, 1992-2005 34 6 American Society for Investigative Pathology, 1987-2005 34 7 American Society for Neurochemistry, 1996-2001 34 8 American Association of Pathology Chairs, 2001-2004 34 9 Cleveland Society of Pathologists, 1988-1997 34 10 Federation of American Societies for Experimental Biology (FASEB), 1996-2000 34 11 First International Congree on Alzheimer's Disease, 1987-1988 34 12 Histology Society of Ohio, 1993 34 13 International College of Geriatric Psychoneuropharmacology, 2001-2003 34 14 International Mailard Reaction Society (IMARS), 2005 34 15 Microscopic Society of America, 1991-1996 34 16 Microscopy Society of Northeastern Ohio, 1995-2004 34 17 Mitocondrion Research Society, 1999 34 18 Mytosis Association, 2005 34 19 Sigma Xi, 1997-2006 34 20 Society for Neuroscience, 1996-2004 34 21 Society of Neuroscientists in Africa (SONA), 1994-1997 34 22 United States and Canada Academy of Pathologists, 2000-2005 34 23 Universities Associated for Research and Education in Pathology, 2002 34 24 University Pathologists of Cleveland, 1986-1993 5116Laboratory notes 1982-1988Conferences

Correspondence and conference proceedings related to professional conferences organized alphabetically by title.

 38 15 2nd European Ipsen Symposium, 2005 38 6 35th Annual Meeting of the American Society for Neurochemistry, 2004 38 16 4th International Congress on Vascular Dementia, 2005 38 12 7th International Conference on Alzheimer's and Parkinson's Diseases, 2005 38 7 8th International Symposium on the Malliard Reaction, 2004 33 12 Alzheimer's Disease: The Therapeutic Era, 1998 33 18 American College of Neuropsychopharmacology, 1999 38 1 Case Western Reserve School of Medicine Education Retreat, 2004 38 4 Challenging Views of Alzheimer's Disease, 2004 38 14 Experimental Biology, 2005 33 3 Fifth International Conference on Alzheimer's Disease and Related Disorders, 1996 33 11 Fourth Hungarian Conference on Alzheimer's Disease, 1998 33 2 Fourth International Congress of Movement Disorders, 1996 33 19 Fourth International Symposium on Medical Chemistry of Neurodegenerative Diseases, 2000 33 8 Gordon Conference, Intermediate Filaments 1998, 1995-2002 33 6 Gordon Conference, Oxygen Radicals in Biology, 1998 Gordon Conference. Oxidative Stress and Disease 33 14 1999 33 23 2001 38 11 International Conference on Inclusion-Body Myositis, 2005 33 22 International Society for Free Radical Research, 2000 38 13 International Symposium on Aging and Neurodegeneration, 2005 38 17 International Symposium on the Biology of Brain and Mind Disorders, 2005 38 9 KCIST, 2004 33 7 Manhattan Alzheimer's Disease Conference, 1998 33 4 Microscopy and Microanalysis, 1997 33 10 Molecular and Genomic Effects of Tissue Oxygen Deprivation in Sleep Apnea, 1998 33 21 Neuromuscular Disorders and Aging, 2000 33 15 Neuronal Apoptosis, 1999 38 8 New Approaches in Alzheimer's Disease Therapy, 2004 33 17 NIA Imaging and Biological Markers for Diagnosis of Alzheimer's Disease, 1999 38 5 Ninth International Conference on Alzheimer's Disease and Related Disorders, 2004 Oxygen Club of California 33 5 1998 33 13 1999 38 3 Portuguese Dementia Group, 2004 33 9 Sixth International Conference on Alzheimer's Disease and Related Disorders, 1998 33 16 Sixth Meeting of the Portuguese Society of Neuroscience, 1999 38 10 Third International Workshop on Iron and Copper Homeostatis, 2004 38 2 Twelfth Biennial Meeting of the Society for Free Radical Research International, 2004 33 20 World Alzheimer Congress, 2000 Return to Part 1 of the George Perry papers