The Board of Deacons oversees the operations of the church. It is responsible for managing the church's business affairs, care and maintenance of the church's physical property, preparation of the church's annual budget, advising the elders of the financial condition of the church, receiving and counting the offerings of the congregation, conducting the annual canvass of the church members to secure the budget, and visiting the sick church members and strangers who have visited the church. The Board holds regular monthly meetings as well as special meetings when circumstances warrant them. Deacons serve on committees that oversee various aspects of church operations. This series consists of Diaconate meeting minutes dating from 1886 to 1989.

Ruling elders in the Presbyterian Church are lay persons elected to govern the congregation. The Presbyterian Church recognizes three offices in the church, that of deacon, ruling elder and teaching elder. A teaching elder is a minister. Each office requires ordination.

The Deacons and Elders periodically hold meetings together. The records for many of the meetings held prior to 1946 can be found with the Board of Deacons' minutes.

This series contains church membership information. It includes registers which cover a span of years, in which names were entered alphabetically, and membership lists and directories, which give a picture of the membership at a particular point in time. Also included in this series are lists of members who have died or been dismissed to other churches, as well as lists of baptisms, weddings, and funerals.

Around 1980, church staff members searched the minutes of the church officer meetings and the Congregational meetings from about 1910-1950, and organized the material topically. Photocopies of pages of meeting minutes dealing with similar topics were placed together. Some of this information is duplicated elsewhere in the collection; however, the topical organization as it exists here is unique. For this reason, these materials were kept with the rest of the collection.

First Presbyterian Church has owned a fair amount of property since its inception. Included are sites of their own church, the manses, and sites of various missions throughout the city. This series consists of property abstracts, building specifications, and other material related to First Presbyterian Church's real estate holdings.

These oral histories, most of which were conducted in the fall of 1987, were used by Judy King in her book .

Thomas Talbot was Associate Pastor at First Presbyterian Church from 1962 to 1978. This series consists of a sample of his office files. Primarily correspondence, it gives a picture of the various activities that pastors at First Presbyterian Church are involved in.

Upon the outbreak of the Civil War in 1861, the northern and southern branches of the Presbyterian Church in the United States split into separate denominations. They existed as such for over 120 years, until they reunited in 1984. The northern denomination had been known as the United Presbyterian Church in the U.S.A., and the southern denomination as the Presbyterian Church in the United States; the reunited denomination was known as the Presbyterian Church (U.S.A.). As part of the unification agreement, an "escape clause", known as Article 13 of the agreement, allowed churches that had formerly been in the southern denomination to leave the union within 7 years if a majority of the members of their congregations voted to do so. In 1990, a group of First Presbyterian Church members wished to exercise article 13. These members preferred to ally First Presbyterian Church with one of two small Presbyterian denominations: The Evangelical Presbyterian Church or the Presbyterian Church of America.

This series contains biographical material and reminiscences of various people involved with First Presbyterian Church throughout its history.